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3 edition of The binding of pili from neisseria gonorrhoeae and neisseria meningitidis to human erythrocytes found in the catalog.

The binding of pili from neisseria gonorrhoeae and neisseria meningitidis to human erythrocytes

Jane Dollie Stephenson

The binding of pili from neisseria gonorrhoeae and neisseria meningitidis to human erythrocytes

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Published .
Written in English


Edition Notes

Statementby Jane Dollie Stephenson.
Classifications
LC ClassificationsMicrofilm 86/1023 (Q)
The Physical Object
FormatMicroform
Paginationvi, 208 leaves
Number of Pages208
ID Numbers
Open LibraryOL2357069M
LC Control Number86890594

Neisseria gonorrhoeae, is an exclusive human pathogen that primarily infects the urogenital epithelia, causing the sexually transmitted disease gonorrhoea. Entry of N. gonorrhoeae into human epithelial cells is multifactorial. Initial attachment is mediated by pili (a T4SS), followed by tight adherence via the phase-variable colony opacity (Opa Cited by: 1.


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The binding of pili from neisseria gonorrhoeae and neisseria meningitidis to human erythrocytes by Jane Dollie Stephenson Download PDF EPUB FB2

The binding of PilC protein efficiently prevented the attachment of piliated Neisseria gonorrhoeae and Neisseria meningitidis to these cell types. Fluorescent beads coated with pili prepared from piliated wild-type N. gonorrhoeae also adhered to these cells, in contrast to beads coated with pili prepared from a piliated PilC-deficient by:   Type IV pili (Tfp) of Neisseria gonorrhoeae, the Gram-negative etiologic agent of gonorrhea, facilitate colonization of the human are assumed to play a key role in the initial adherence to human epithelial cells by virtue of the associated adhesin protein by:   Neisseria gonorrhoeae andNeisseria meningitidis are Gram-negative bacterial pathogens that infect human mucosal epithelia.

Type IV pilus-mediated adherence of these bacteria is a crucial early event for establishment of infection. Pili from a non-binding mutant of N.

meningitidis do not induce Ca 2+ signaling. Meningococcal meningitis and sepsis are devastating diseases which still affect people with an incidence varying between and cases/ depending on the epidemiological areas.

The etiological agent is Neisseria Meningitidis, a gram negative diplococcus and an obligate human pathogen. Meningococcus colonizes the nasopharyngeal mucosa Cited by: In Atlas of Oral Microbiology, Neisseria.

Neisseria are aerobic gram-negative diplococci belonging to the family Neisseriaceae, which mainly colonize the human oral cavity and Neisseria are members of the normal microflora of the human body and are usually nonpathogenic. However, N. meningitidis and N. gonorrhoeae are important pathogens.

Neisseria meningitidis, often referred to as meningococcus, is a Gram-negative bacterium that can cause meningitis and other forms of meningococcal disease such as meningococcemia, a life-threatening bacterium is referred to as a coccus because it is round, and more specifically, diplococcus because of its tendency to form pairs.

About 10% of adults are Class: Betaproteobacteria. A Neisseria meningitidis ou meningococo são bactérias coccus Gram-negativo (CGN), imóveis e aeróbias que se agrupam aos pares, formando diplococos.São de grande importância clínica pois causam meningite meningocócica, uma grave inflamação das membranas que envolvem o ntemente são encontradas em membranas mucosas humanas.

[1Classe: Betaproteobacteria. Neisseria meningitidis and Neisseria gonorrhoeae are human-specific pathogens and possess a range of mechanisms to achieve successful colonization of their unique niches.

The bacteria are closely Cited by: Neisseria gonorrhoeae infects which areas of the body. pili- > serotypes 2. PI- >18 serotypes 3. PIII blocks Abs so there is no interaction with bacteria tubule cilia are damaged by infection and egg can't move along fallopian tube.

Differences between N. gonorrhoeae and N. meningitidis. gonorrhoeae- ferments ONLY glucose. INTRODUCTION. Infection with Neisseria meningitidis can produce a variety of clinical manifestations, ranging from transient fever and bacteremia to fulminant disease with death ensuing within hours of the onset of clinical symptoms.N.

meningitidis is a common cause of community-acquired bacterial meningitis in both children and adults. (See "Bacterial meningitis. The effect of mannan-binding lectin on opsonophagocytosis of Neisseria meningitidis.

Immunopharmacology ; Jack DL, Cole J, Naylor SC, et al. Genetic polymorphism of the binding domain of surfactant protein-A2 increases susceptibility to meningococcal disease.

Abstract. A chemically defined medium was developed that supports growth of various strains of Neisseria recently isolated from clinical material. Quantitative tests were made of seven strains of Neisseria gonorrhoeae cultivated in the defined fluid medium. When inoculated at concentrations of 2 × 10 5 –6 × 10 6 cfu/ml, the gonococci multiplied with generation times ≤ Cited by: Also, Pili and Opas interfere w/ effective phagocytosis.

Describe genetic mechanisms of gonococcal antigenic variation Gonococcus uses Recombinational and Translational genetic mechanisms to change both Pili and Opa during the course of human infections. Pili and pilin antigenic variation play important roles in adhesion of Neisseria meningitidis (MC) to human epithelial and endothelial cells.

We recently identified one pilin variant that confers high adhesiveness of MC to human epithelial cells in by: Neisseria gonorrhoeae is a good example of a Gram-negative pathogen that very easily acquire resistance. In gonococcus, as in other bacteria, the emergence and spread of resistance due to.

Neisseria meningitidis (meningococcus) and N. gonorrhoeae (gonococcus), the well-known agents of epidemic meningitis and gonorrhea, respectively, are Gram-negative bacteria that specifically. Neisseria Meningitidis is a bacteria that is best known for its role in endemic bacterial meningitis.N.

Meningitidis is described as a gram-negative diplococci. The fact that this bacteria is gram negative means that there is very little or no peptidoglycan in the cell wall.

Neisseria meningitidis: Pathogenesis and immunity Article (PDF Available) in Current Opinion in Microbiology 23C November with 1, Reads How we measure 'reads'. The major adhesins of pathogenic Neisseria are the type IV pili, Opa and in case of itidis Opc, minor adhesins are the adhesion penetration protein (App) and for itidis Neisseria.

Thirteen Neisseria meningitidis serogroups have been described on the basis of serologic differences of the capsule; of these 13 serogroups, 6 (A, B, C, W, X, Y) cause invasive meningococcal disease.

The polysaccharide capsule is a key virulence determinant, and for serogroups A, C, W, and Y, it forms the basis of polysaccharide conjugate vaccines.

Meningococcal disease is an acute, potentially severe illness caused by the bacterium Neisseria meningitidis. Illness believed to be meningococcal disease was first reported in the 16th century.

The first definitive description of the disease was by Vieusseux in Switzerland in The bacterium was first identified in the spinal fluid of. Meningococcal disease: isolation of Neisseria meningitidis from normally sterile site in a resident of a surveillance area in ABCs Methodology.

ABCs personnel routinely contacted all microbiology laboratories serving acute care hospitals in their area to identify cases. Neisseria meningitidis with Reduced Susceptibility to Ciprofl oxacin To the Editor: Reduced suscep-tibility to ciprofl oxacin of Neisseria meningitidis has been reported with increasing frequency sincemainly because of mutations in the quinolone resistance determining re-gions (QRDRs) of the gyrase and topoisomerase IV genes (1,2).

Re. Neisseria Meningitidis (Meningococcal Disease) - 3 b. Appropriate suspending vehicle or syrup vehicle can be used for liquid suspension rifampin orders. Ceftriaxone given in a single intramuscular dose is effective in eradicating carriage. Ciprofloxacin, administered to adults in a single oral dose is effective in.

In bacteria. Antigenic variation in bacteria is best demonstrated by species of the genus Neisseria (most notably, Neisseria meningitidis and Neisseria gonorrhoeae, the gonococcus); species of the genus Streptococcus and the Neisseria species vary their pili (protein polymers made up of subunits called pilin which play a critical role in bacterial adhesion, and stimulate a.

The N. gonorrhoeae Sma/Cla repeat, implicated in enhancing pilE/S recombination in N. gonorrho exists as a single copy in N. meningitidis Z, immediately downstream of the pilE gene. The two pathogenic species of Neisseria, N. meningitidis and N. gonorrhoeae, have evolved resistance to penicillin by alterations in chromosomal genes encoding the high molecular weight penicillin-binding proteins, or PBPs.

The PBP 2 gene (penA) has been sequenced from over 20 Neisseria isolates, including susceptible and resistant strains of the Cited by: Neisseria meningitidis is immediately reportable on first knowledge or suspicion of the diagnosis due to the potential need for prophylaxis of close contacts within 24 hours of suspected diagnosis (suspicion is normally based on gram stain results – see table on page 4).

All other cases of bacterial meningitis areFile Size: KB. Nationally Notifiable Conditions Conditions designated as notifiable at the national level during INTRODUCTION. Neisseria gonorrhoeae (gonococcus) is an obligate human pathogen and the etiological agent of gonorrhea, an ancient disease (Leviticus –3, Old Testament).

Gonococcal transmission occurs primarily from an infected individual by direct contact between the mucosal membranes of the urogenital tract, anal canal, oropharynx, and occasionally eye Cited by: Neisseria Meningitidis will attach to the microvilli of nonciliated columnar epithelial cells that reside in the nasal region of humans.

The bacteria are able to multiply and form a colony because of its ability to acquire iron from the host. The bacteria are then able to invade the mucous membrane that lines the nasopharnyx. The reservoir for Neisseria meningitidis (Nm) is the human oropharynx.

Implementation of Nm serogroup C (NmC) glycoconjugate vaccines directly reduced NmC carriage. Prophylactic vaccines are now available to prevent disease caused by the five major Nm disease causing serogroups (ABCWY).

Nm serogroup B (NmB) vaccines are composed of antigens that are Cited by: 8. Introduction. Neisseria meningitidis, the meningococcus, is a Gram‐negative bacterium belonging to the β‐ species' natural habitat is the human nasopharynx.

Animal or environmental habitats are unknown. Asymptomatic colonization of the retropharyngeal wall and the tonsils is observed at high frequency in the second decade of life.

Abstract. Moderate penicillin resistance in the human pathogen Neisseria meningitidis emerged seven years ago in Spain (Saez-Nieto and Campos ). Since the first isolate inthe frequency of Pen R strain isolation is increasing especially in the area surrounding Barcelona (reaching 40% in ).Author: J.

Campos, M. Fusté, J. Vazquez, J. Saez-Nieto, M. Viñas. Abstract. Neisseria meningitidis is a strictly human pathogen and is one of the major causes of septicemia and meningitis worldwide. Functional genomics approaches have been extensively applied to study how N. meningitidis adapts to grow and survive in different human niches encountered during the infection.

DNA microarrays performed in in vitro and ex Cited by: 5. Neisseria meningitidis (Albrecht and Ghon) Murray ATCC ® ™ freeze-dried For-Profit: $ Non-Profit: $ Introduction. Neisseria meningitidis, the meningococcus, is a harmless commensal of the human carrier state is usually asymptomatic and essential for transmission.

Invasion of the pharyngeal tissues and subsequent proliferation in the blood and cerebrospinal fluid are infrequent, but lead to life-threatening diseases such as septicemia and meningitis, which are. meningitis caused by the bacteria Neisseria meningitidis or certain forms of Haemophilus.

When a single instance of Neisseria meningitidis occurs, the state and county health departments work together to insure that appropriate contacts obtain antibiotics.

Only people who have been in close contact with saliva or respiratory. Type 1 fimbriae bind to mannose containing receptors. Whilst P fimbriae allow binding to galactose containing glycolipids (e.g.

cerebrosides) and glycoproteins present on epithelial cells. They are referred to as "P" fimbriae since they were originally shown to bind to P blood group antigens on human erythrocytes. Penetration and spread. Meningococcal meningitis. The term meningitis is often applied to meningococcal meningitis, which is caused by Neisseria meningitidis, known commonly as ococcal meningitis is worldwide in distribution.

It is primarily a disease of youth and especially of children under though all ages may be affected. Epidemics of meningococcal meningitis took. standardized for rapid detection of meningococcal-specific antibodies in human serum.

We inves-tigated the level of meningococcal-specific IgG, IgA, and IgM in serum using dot-ELISA with outer membrane antigens prepared from Neisseria meningitidis serotype BP,3,7,9 (a strain iso-lated from a Brazilian epidemic).Invasive meningococcal disease is a severe infection caused by a bacterium called Neisseria meningitidis.

Since the introduction of routine meningococcal immunization, the rates of meningitis in children have steadily declined. Sincethere .The bacterial pathogen Neisseria meningitidis expresses two major outer-membrane porins.

PorA expression is subject to phase-variation (high frequency, random, on-off switching), and both PorA and PorB are antigenically variable between by: